Takashima group: The 56th Annual meeting of the Japanese Society for Inherited Metabolic Diseases

Saturday, November 15, 2014

The 56th Annual meeting of the Japanese Society for Inherited Metabolic Diseases

and the 12th Annual Symposium of the Asian Society for Inherited Metabolic Diseases.

11/13-11/15 at Koyo Grand Hotel, Sendai, Miyagi, Japan

ST is presenting a poster
Title: Analysis of the pathology of peroxisomal biogenesis disorder

Welcome to Takashima Group

We study basic and clinical biology of peroxisomes, subcellular micro-organelle which metabolize very long chain fatty acids (VLCFAs), branched fatty acids such as phytanic and pristanic acid, bile acid, and plasmalogens. These metebolites are fundamental to human development and physiology therefore cause human diseases when affected.

Our aim is to understand pathogenesis of peroxisomal diseases, which are caused by mutated genes such as PEXs or ABCD1 gene. We use zebrafish, iPS cells from human patients, and patient's biopsy samples for our research. We also establishing the method to evaluate the content of above metabolites using liquid chromatography mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS) as analytical and diagnosis tools.

Takashima group is a part of Prof. Nobuyuki Shimozawa Laboratory, Division of Genomics Research, Life Science Research Center, Gifu University.

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Saturday, November 15, 2014

The 56th Annual meeting of the Japanese Society for Inherited Metabolic Diseases